SG bubbled id queries vs skeleton entity comparison

Mostly as a query to ShotGrid folk, is there a material difference on the back end for comparing id-values of bubbled entities vs using a skeleton entity? It seemingly is slightly faster on a long query to use a skeleton version of an entity for comparisons, but to be honest, there’s too much variance in return time for me to be confident with that assertion.

This is what I’m talking about in syntax:

sg.find(...filters[["", "is", project_id]]...)
sg.find(...filters[["project", "is", {'type':'Project', 'id':project_id}]]...)